期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 42, 页码 5689-5692出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc01815e
关键词
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资金
- Carl-Zeiss Foundation
- Friedrich Schiller University Jena
- State of Thuringia
The first enantioselective phosphonyldifluoromethylation is enabled by the use of diethyl (difluoro(trimethylsilyl)-methyl)phosphonate reagent as a latent pronucleophile in the Lewis base catalyzed substitution of allylic fluorides. The reaction proceeds as a kinetic resolution to produce both the difluoromethylphosphonate products and the remaining fluorides in good yields and with high stereoselectivity. The use of cinchona based alkaloid catalysts enables the facile synthesis of both enantiomers of the difluoromethylphosphonate products.
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