期刊
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
卷 11, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s40104-020-00463-0
关键词
Mitochondrial morphology; Oxidative stress; Piglets; Skeletal muscle; Taurine
资金
- National Key RD Program [2018YFD0500405]
- National Nature Science Foundation of China [31972582]
- Science and technology projects of Changsha City [kq1801059]
- STS regional key projects of Chinese Academy of Sciences [KFJ-STS-QYZD-052]
- Youth Innovation Team Project of ISA, CAS [2017QNCXTD_ZCS]
- Earmarked Fund for China Agriculture Research System [CARS-35]
Background Oxidative stress is a key factor that influences piglets' health. Taurine plays an imperative role in keeping the biological system from damage. This study was conducted to investigate the protective effect of taurine against muscle injury due to the secondary effect of diquat toxicity. Results Our study found that taurine effectively and dose-dependently alleviated the diquat toxicity induced rise of feed/gain, with a concurrent improvement of carcass lean percentage. The plasma content of taurine was considerably increased in a dose-dependent manner. Consequently, dietary taurine efficiently improved the activity of plasma antioxidant enzymes. Furthermore, taurine attenuated muscle damage by restoring mitochondrial micromorphology, suppressing protein degradation and reducing the percentage of apoptotic cells in the skeletal muscle. Taurine supplementation also suppressed the genes expression levels of the antioxidant-, mitochondrial biogenesis-, and muscle atrophy-related genes in the skeletal muscle of piglets with oxidative stress. Conclusions These results showed that the dose of 0.60% taurine supplementation in the diet could attenuate skeletal muscle injury induced by diquat toxicity. It is suggested that taurine could be a potential nutritional intervention strategy to improve growth performance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据