Recent Advance in the Transition-Metal-Catalyzed Carbene Insertion Reactionsof Si-H Bond

Organosilicon compounds have been widely used in organic synthesis, biomedicine, material science and other fields. The development of simple and efficient C-Si bond construction methodology has attracted extensive attention from scientists. Transition-metal-catalyzed carbene insertion reaction of Si-H bond is one of the important methods to form C-Si bond. It not only has the advantages of simple operation, mild reaction conditions and high atom economy, but also can be used to synthesize various chiral organosilanes with high enantioselectivity through the regulation of chiral ligands. In recent Years, achieved rapid development has been in this field, and various new carbene Precursors and metal catalytic systems have been emerged. According to the group of transition metal elements, recent advance in the iron, copper, zinc, ruthenium, rhodium palladium, silver iridium and gold catalyzed carbene insertion reactions of Si-H bond since 2012 is reviewed in five parts.