期刊
CHINESE JOURNAL OF ORGANIC CHEMISTRY
卷 40, 期 4, 页码 922-929出版社
SCIENCE PRESS
DOI: 10.6023/cjoc201910011
关键词
trifluoromethylated acylhydrazones; trimethylsilyl cyanide; acylhydrazides; hydrocyanation
资金
- National Natural Science Foundation of China [21662030, 21861033]
The Lewis acid catalyzed 1,2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated, and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield. The method could be easily operated in mild reaction conditions, which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.
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