期刊
NEUROCHEMICAL JOURNAL
卷 14, 期 2, 页码 191-196出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1819712420020075
关键词
paternal stress; post-traumatic stress disorder; offspring; memory; insulin-like growth factor II gene; rat
资金
- Russian Foundation for Basic Research [18-015-00186]
We studied the capability to learn in a passive avoidance task and the rate of its extinction in male rats whose fathers were subjected to stress during the period of spermatogenesis using the stress-restress paradigm (a model of post-traumatic stress disorder). In the brain of trained and untrained rats, we studied the expression of genes encoding insulin-like growth factor II and H19, the expression of which is imprinted at the early stages of ontogeny. Experimental males exhibited impaired memory consolidation and accelerated extinction of a passive avoidance response. The expression of Igf2 was decreased in the hippocampus and neocortex of untrained male offspring of stressed fathers. The increased expression of theIgf2andH19genes was revealed in the hippocampus of male offspring of control fathers 20 h after training, whereas in the experimental rats, the expression of these genes did not alter. Our data show that the impairment of memory in male offspring of stressed fathers may be mediated by decreased expression of theIgf2gene.
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