期刊
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
卷 99, 期 1, 页码 165-172出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2017.05.001
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资金
- US National Cancer Institute [NCI 1RO1CA152192]
Purpose: To determine whether adjuvant radiation therapy (RT) is associated with adverse patient-reported outcomes and surgical complications 1 year after skinsparing mastectomy and immediate autologous free flap reconstruction for breast cancer. Methods and Materials: We compared 24 domains of patient-reported outcome measures 1 year after autologous reconstruction between patients who received adjuvant RT and those who did not. A total of 125 patients who underwent surgery between 2012 and 2015 at our institution were included from the Mastectomy Reconstruction Outcomes Consortium study database. Adjusted multivariate models were created incorporating RT technical data, age, cancer stage, estrogen receptor, chemotherapy, breast size, body mass index, and income to determine whether RT was associated with outcomes. Results: At 1 year after surgery, European Organisation for Research and Treatment of Cancer (EORTC) Breast Cancer-Specific Quality of Life Questionnaire breast symptoms were significantly greater in 64 patients who received RT (8-point difference on 100-point ordinal scale, P<. 0001) versus 61 who did not receive RT in univariate and multivariate models. EORTC arm symptoms (20-point difference on 100-point ordinal scale, PZ. 0200) differed on univariate analysis but not on multivariate analysis. All other outcomesdincluding Numerical Pain Rating Scale, BREASTQ (Post-operative Reconstruction Module), Patient-Report Outcomes Measurement Information System Profile 29, McGill Pain QuestionnaireeShort Form (MPQ-SF) score, Generalized Anxiety Disorder Scale, and Patient Health Questionnaireewere not statistically different between groups. Surgical complications were uncommon and did not differ by treatment. Conclusions: RT to the neo-breast compared with no RT following immediate autologous free flap reconstruction for breast cancer is well tolerated at 1 year following surgery despite patients undergoing RT also having a higher cancer stage and more intensive surgical and systemic treatment. Neo-breast symptoms are more common in patients receiving RT by the EORTC Breast Cancer-Specific Quality of Life Questionnaire but not by the BREAST-Q. Patient-reported results at 1 year after surgery suggest RT following immediate autologous free flap breast reconstruction is well tolerated. (C) 2017 Elsevier Inc. All rights reserved.
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