期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 35, 期 -, 页码 109-115出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.10.007
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资金
- BBSRC [BB/G020671/1]
- Biotechnology and Biological Sciences Research Council [BB/G020671/1, BB/G020671/2] Funding Source: researchfish
- BBSRC [BB/G020671/2] Funding Source: UKRI
It has until recently been unclear whether outer membrane proteins (OMPs) of Gram-negative bacteria are organized or distributed randomly. Studies now suggest promiscuous protein-protein interactions (PPIs) between beta-barrel OMPs in Escherichia coli govern their local and global dynamics, engender spatiotemporal patterning of the outer membrane into micro-domains and are the basis of p-barrel protein turnover. We contextualize these latest advances, speculate on areas of bacterial cell biology that might be influenced by the organization of OMPs into supramolecular assemblies, and highlight the new questions and controversies this revised view of the bacterial outer membrane raises.
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