期刊
FEMS MICROBIOLOGY LETTERS
卷 367, 期 14, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnaa109
关键词
antibiotic resistance; Achromobacter xylosoxidans; class 1 integron; In687; horizontal gene transfer; AcGI1
类别
资金
- Mahidol-Liverpool Chamlong Harinasuta PhD scholarship
- Wellcome Trust ISSF tenure track fellowship
This study investigated the genetic basis of multidrug resistance in two strains of Achromobacter xylosoxidans isolated from patients attending a hospital in Thailand in 2012. These isolates were highly resistant to cephalosporins, aminoglycosides, fluoroquinolones, co-trimoxazole and carbapenems. Whole genome sequencing revealed that the two isolates were not clonally related and identified a carbapenem resistance gene-habouring integron (In687), residing in a novel genomic island, AcGI1. This In687 shares 100% identical nucleotide sequence with ones found in Acinetobacter baumannii Aci 16, isolated from the same hospital in 2007. We report the first analysis of multidrug-resistant A. xylosoxidans isolated in Thailand, and the first example of this island in A. xylosoxidans. Our data support the idea that resistance has spread in Thailand via horizontal gene transfer between species and suggest the possibility of A. xylosoxidans may serve as a reservoir of antibiotic resistance, especially in hospital setting. The first identification of a novel genomic island, AcGI1, containing multiple antimicrobial resistance genes in A. xylosoxidans.
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