期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 30, 期 -, 页码 161-169出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.02.008
关键词
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资金
- Swiss National Science Foundation [PZ00P2_136856]
- Swiss National Science Foundation (SNF) [PZ00P2_136856] Funding Source: Swiss National Science Foundation (SNF)
Why do chaperones need ATP hydrolysis to help proteins reach their native, functional states? In this review, we highlight the most recent experimental and theoretical evidences suggesting that ATP hydrolysis allows molecular chaperones to escape the bounds imposed by equilibrium thermodynamics. We argue here that energy consumption must be fully taken into account to understand the mechanism of these intrinsically non-equilibrium machines and we propose a novel perspective in the way the relation between function and ATP hydrolysis is viewed.
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