期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 30, 期 -, 页码 63-70出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.01.002
关键词
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资金
- UK Medical Research Council [MC_PC_13051, U117565647]
- University College London
- Medical Research Council [MC_U117574558, MC_PC_13051] Funding Source: researchfish
- The Francis Crick Institute [10178] Funding Source: researchfish
- MRC [MC_U117574558, MC_PC_13051] Funding Source: UKRI
The hnRNP K-homology (KH) domain is a single stranded nucleic acid binding domain that mediates RNA target recognition by a large group of gene regulators. The structure of the KH fold is well characterised and some initial rules for KH RNA recognition have been drafted. However, recent findings have shown that these rules need to be revisited and have now provided a better understanding of how the domain can recognise a sequence landscape larger than previously thought as well as revealing the diversity of structural expansions to the KH domain. Finally, novel structural and functional data show how multiple KH domains act in a combinatorial fashion to both allow recognition of longer RNA motifs and remodelling of the RNA structure. These advances set the scene for a detailed molecular understanding of KH selection of the cellular targets.
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