期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 7, 页码 665-681出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.05.005
关键词
eosinophil; remodeling; STEMI
资金
- British Heart Foundation Centre of Research Excellence
- Wellcome Trust Edinburgh Clinical Academic Track fellowship [104799/Z/14/Z]
- Medical Research Council-UK Programme Grant [MR/K013386/1, MR/K01207X/1]
- British Heart Foundation [CH/09/002, RE/13/3/30183, RM/13/2/30158, RG/16/10/32375]
- Wellcome Trust [WT103782AIA]
- Medical Research Council-UK Project grant [MR/P02615X/1]
- Wellcome Trust [104799/Z/14/Z] Funding Source: Wellcome Trust
- MRC [MR/M011542/1, MR/K013386/1, MR/K01207X/1, MR/K01207X/2] Funding Source: UKRI
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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