期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 30, 期 -, 页码 89-99出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.02.001
关键词
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资金
- BBSRC [BB/G019452/1]
- ERC [32240]
- Biotechnology and Biological Sciences Research Council [BB/G019452/1] Funding Source: researchfish
- BBSRC [BB/G019452/1] Funding Source: UKRI
Force can drive conformational changes in proteins, as well as modulate their stability and the affinity of their complexes, allowing a mechanical input to be converted into a biochemical output. These properties have been utilised by nature and force is now recognised to be widely used at the cellular level. The effects of force on the biophysical properties of biological systems can be large and varied. As these effects are only apparent in the presence of force, studies on the same proteins using traditional ensemble biophysical methods can yield apparently conflicting results. Where appropriate, therefore, force measurements should be integrated with other experimental approaches to understand the physiological context of the system under study.
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