期刊
GREEN CHEMISTRY
卷 22, 期 11, 页码 3506-3511出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0gc01183e
关键词
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资金
- Ministry of Science and Technology (MOST), Taiwan
- Centre for Research and Development of Kaohsiung Medical University
The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O-2 and TsOH center dot H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.
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