期刊
CURRENT OPINION IN STRUCTURAL BIOLOGY
卷 30, 期 -, 页码 134-146出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2015.02.011
关键词
-
资金
- University of North Carolina at Chapel Hill
- March of Dimes Foundation
Conformational dynamics is a hallmark of diverse non-coding RNA functions. During these functional processes, RNA molecules almost ubiquitously undergo conformational transitions that are tuned to meet distinct structural and kinetic requirements for proper function. A complete mechanistic understanding of RNA function requires comprehensive structural and dynamic knowledge of these complex transitions, which often involve alternative higher-energy conformational states that pose a major challenge for highresolution structural study by conventional methods. In this review, we describe recent progress in RNA NMR that has started to unveil detailed structural, thermodynamic and kinetic insights into some of these excited conformational states of RNA and their functional roles in biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据