期刊
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
卷 66, 期 11, 页码 558-568出版社
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2016.1252351
关键词
Arothron stellatus; collagen; tissue engineering; wound healing
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi, India [31/6(395)/2014-EMR-I]
- CSIR [OLP-09/TRP]
The wound dressing material has been fabricated with the novel Arothron stellatus fish skin collagen scaffold loaded with a bioactive extract obtained from Coccinia grandis (CPE) and drug Ciprofloxacin (D). The collagen scaffold was fabricated from the nonedible solid waste of marine origin (a cheaper source of raw material). The in vitro fluorescence staining of cells and in vivo evaluation of the fabricated scaffold exhibited enhanced cell adhesion and proliferation and indicated a more efficient wound healing paradigm than that of the control and other treated groups, respectively. The increased collagen synthesis and re-epithelialization of wound are proved to be potential wound constructs.
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