期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 27, 期 2, 页码 204-211出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0000000000000150
关键词
chemokines; inflammation; leukocytes; migration; rheumatoid arthritis
类别
资金
- Medical Research Council (UK) Program grant
- Medical Research Council [G0901113] Funding Source: researchfish
- MRC [G0901113] Funding Source: UKRI
Purpose of review To provide an update of past failures, future prospects and key challenges facing the therapeutic targeting of chemokines and their receptors in rheumatoid arthritis. Recent findings Clinical trials in rheumatoid arthritis have been undertaken with small molecule antagonists or neutralizing antibodies targeting CCR1, CCR5 and CXCL10. Some encouraging results have emerged. Laboratory and clinical research has identified CCL19, CXCL13 and CXCL12, and their receptors, as potential future targets. Developments in our appreciation of posttranslational chemokine modification highlight the complexity of chemokine networks operating in inflamed tissues, and the substantial gaps in existing knowledge. Summary Despite previous disappointments, there are still reasons to be optimistic that drugs targeting chemokines and their receptors could be developed for the treatment of rheumatoid arthritis. However, a deeper understanding of the chemokine networks at work in inflamed joints is a necessary prerequisite.
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