期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 523, 期 2, 页码 441-453出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2016.09.044
关键词
Gelatin; Electrospun scaffolds; Tissue engineering; Biopolymers
资金
- CONICET
- Argentinean National Agency of Scientific and Technological Promotion [PICT 224]
- National Research Council of Argentina CONICET [PIP 0089]
The development of biomimetic highly-porous scaffolds is essential for successful tissue engineering. Electrospun nanofibers are highly versatile platforms for a broad range of applications in different research areas. In the biomedical field, micro/nanoscale fibrous structures have gained great interest for wound dressings, drug delivery systems, soft and hard-tissue engineering scaffolds, enzyme immobilization, among other healthcare applications. In this mini-review, electrospun gelatin-based scaffolds for a variety of tissue engineering applications, such as bone, cartilage, skin, nerve, and ocular and vascular tissue engineering, are reviewed and discussed. Gelatin blends with natural or synthetic polymers exhibit physicochemical, biomechanical, and biocompatibility properties very attractive for scaffolding. Current advances and challenges on this research field are presented. (C) 2016 Elsevier B.V. All rights reserved.
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