期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 531, 期 1, 页码 292-298出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2017.08.115
关键词
Nanostructured lipid carriers; Voriconazole; Nail delivery; Onychomycosis
资金
- National Council for the Research and Development (CNPq) of Brazilian Government [44644/2014-2]
- Coordination for Higher Education Personnel Improvement (CAPES)
- Research support foundation of the Federal District (FAPDF)
Voriconazole-loaded nanostructured lipid carriers (VOR-NLC) were developed and drug penetration evaluated in porcine hooves in vitro. Synergistic effect of urea (Ur), selected among other known chemical enhancers according to hoof hydration potential, was also evaluated. VOR-NLC presented a high encapsulation efficiency (74.52 +/- 2.13%), approximate mean diameter of 230 nm and were positively charged (+ 27.32 +/- 2.74 mV). Stability studies indicated they were stable under refrigeration (4 +/- 2 degrees C) for up to 150 days. SEM images revealed hooves treated with VOR-NLC and VOR-NLC-Ur suffered a disturbance on the surface depicting high roughness and porosity. Permeation data showed a substantial VOR amount retained in superficial hooves sections independent of the formulation used (2.42 +/- 0.26; 2.52 +/- 0.36 and 2.41 +/- 0.60 mu g/cm(2) for unloaded VOR, VOR-NLC and VOR-NLC-Ur, respectively, p > 0.05). Still, successive extractions, revealed the amount of VOR retained in deeper regions was significantly higher when VOR-NLC or VOR-NLC-Ur was used (0.17 +/- 0.04, 0.47 +/- 0.14 and 0.36 +/- 0.07 mu g/cm(2) for un-loaded VOR, VOR-NLC and VOR-NLC-Ur, respectively, p < 0.05). Such results indicate NLC are promising formulations for the management of onychomycosis. Further studies in diseased nail plates are necessary.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据