期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 516, 期 1-2, 页码 364-371出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2016.11.046
关键词
Solid lipid nanoparticles; Yuxingcao essential oil; Pulmonary delivery; Pulmonary retention; Sustained release; Traditional Chinese medicine
资金
- National Natural Science Foundation of China [81172997]
- Ministry of Science and Technology of the People's Republic of China [2012ZX09301-002-030]
- PUMC Youth Fund from the Fundamental Research Funds for the Central Universities grants of the People's Republic of China [3332015202]
- Beijing Natural Science Foundation [7164280]
The objective of this study was to prepare solid lipid nanoparticles (SLNs) for sustained pulmonary delivery of Yuxingcao essential oil (YEO). Three YEO loaded SLNs (SLN-200, SLN-400 and SLN-800) with different particle size were prepared and separated following a high-shear homogenization technique using Compritol 888 ATO as lipid and polyvinyl alcohol as an emulsifier. The particle size, zeta potential, drug encapsulation efficiency and drug loading of the SLNs were determined to be between 171 and 812 nm, -17.1 and -19.3 mV, between 76.6 and 90.2% and between 2.34 and 3.12%, respectively whereas the in vitro release data showed that the SLNs led to sustained drug release up to 48 h. In addition, the SLN suspensions after nebulization conferred the fine particle fractions (<5.4 mu m) of 67.4-75.8%. Following intratracheal administration to rats, YEO loaded SLNs not only prolonged pulmonary retention up to 24 h, but also increased AUC values (15.4, 18.2 and 26.3 mu g/g h for SLN-200, SLN-400 and SLN-800, respectively) by 4.5-7.7 folds compared to the intratracheally dosed YEO solution and by 257-438 folds to the intravenously dosed YEO solution, respectively. The present results were the first to show that YEO loaded SLNs may sustain YEO inhalation delivery and improve local bioavailability, representing a promising inhalable carrier to attain once daily application. (C) 2016 Published by Elsevier B.V.
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