期刊
CURRENT OPINION IN RHEUMATOLOGY
卷 27, 期 1, 页码 91-98出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/BOR.0000000000000136
关键词
genetic epidemiology; psoriatic disease; risk factors
类别
资金
- Janssen PsA fellowship
- Arthritis Society
- CIHR
- Krembil Foundation
- Canadian Institutes of Health Research (CIHR) fellowship award
Purpose of reviewTo review recent evidence for genetic susceptibility in psoriasis and psoriatic arthritis.Recent findingsPsoriasis and psoriatic arthritis (PsA) have substantive genetic determinants as indicated by their high family aggregation. Psoriasis and PsA share several susceptibility genes; however, other genes, mostly within the major histocompatibility complex (MHC) region, confer an independent risk for PsA. The human leukocyte antigen-C0602 allele confers the highest risk for psoriasis whereas several human leukocyte antigen-B alleles were identified as PsA-specific' genes. Fine mapping of the MHC suggests that glutamine at position 45 is an important susceptibility factor for PsA. Additional genes outside of the MHC region were identified as psoriasis susceptibility genes. These genes belong to several proinflammatory pathways and skin barrier mechanisms that play a role in the pathogenesis of psoriatic disease.SummaryThe MHC remains the major susceptibility locus for psoriatic disease. Future studies using next-generation sequencing technologies may reveal novel rare susceptibility genes for this disease.
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