期刊
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
卷 26, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1076029620932228
关键词
atrial fibrillation; sepsis; chronic kidney disease; hemodialysis; procalcitonin; biomarkers
资金
- National Heart, Lung and Blood Institute of the National Institutes of Health [T35HL120835]
Cardiovascular disease and infection are the leading causes of mortality in patients with stage 5 chronic kidney disease on hemodialysis (CKD5-HD). Inflammation is a large component in the pathogenesis of both atrial fibrillation (AF) and sepsis and may link these conditions in CKD5-HD. Procalcitonin (PCT) is an inflammatory biomarker elevated in systemic infection and CKD5-HD, yet its value with regard to comorbid AF has not been thoroughly investigated. The aim of this study sought to evaluate circulating inflammatory markers, including PCT, Angiopoietin-1, Angiopoetin-2, CD40-L, C-reactive protein,d-dimer, and von Willebrand factor in relation to these conditions. Plasma levels of inflammatory markers were measured by enzyme linked immunosorbent assay method in CKD5-HD (n = 97) patients and controls (n = 50). Procalcitonin levels were significantly elevated (P= .0270) in CKD5-HD with comorbid AF compared to those without AF. Further analysis of patients with a history of sepsis demonstrated significantly elevated levels of PCT (P= .0405) in those with comorbid AF (160.7 +/- 39.5 pg/mL) compared to those without AF (117.4 +/- 25.3 pg/mL). This study demonstrates that the inflammatory biomarker PCT is further elevated in the presence of both AF and a history of sepsis in hemodialysis patients and suggests that underlying chronic inflammation following sepsis resolution may place these patients at greater risk of developing AF.
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