期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 528, 期 1-2, 页码 586-594出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpharm.2017.06.025
关键词
Mucoadhesion; Biomimetic; Soft matter; Mucosal drug delivery; Semi-solid dosage forms
Mucosa-mimetic materials are synthetic substrates which aim to replace animal tissue in mucoadhesion experiments. One potential mucosa-mimetic material is a hydrogel comprised of N-acryloyl-Dglucosamine and 2-hydroxyethylmethacrylate, which has been investigated as a surrogate for animal mucosae in the mucoadhesion testing of tablets and solution formulations. This study aims to investigate the efficacy of this mucosa-mimetic material in the testing of thermogelling semi-solid formulations, which transition from solution to gel upon warming. Two methods for assessing mucoadhesion have been used; tensile testing and a flow-through system, which allow for investigation under dramatically different conditions. It was found that the mucosa-mimetic material was a good surrogate for buccal mucosa using both testing methods. This material may be used to replace animal tissue in these experiments, potentially reducing the number of laboratory animals used in studies of this type. (C) 2017 Elsevier B.V. All rights reserved.
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