期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 22, 页码 4715-4725出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9tb02669j
关键词
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资金
- Hong Kong Baptist University [FRG2/17-18/003]
- Health and Medical Research Fund [HMRF/14150561]
- National Natural Science Foundation of China [21575121, 21775131]
- Hong Kong Baptist University Century Club Sponsorship Scheme 2018
- Interdisciplinary Research Matching Scheme [RC-IRMS/16-17/03]
- Interdisciplinary Research Clusters Matching Scheme [RC-IRCs/17-18/03]
- Collaborative Research Fund [C5026-16G]
- HKBU Strategic Development Fund [SKLP_1718_P04]
- Science and Technology Development Fund, Macau SAR [0072/2018/A2]
- University of Macau [MYRG2018-00187-ICMS, MYRG2019-00002-ICMS]
- SKLEBA [SKLP_1718_P04]
Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.
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