期刊
CURRENT OPINION IN PHARMACOLOGY
卷 21, 期 -, 页码 14-19出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2014.12.003
关键词
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资金
- National Institutes of Health [DK087893-01]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Biomedical Laboratory Research and Development [BX000893-01A2]
- Edna and Fred L. Mandel Center for Hypertension and Atherosclerosis Research
- American Heart Association [12POST11910012]
Accumulating evidence indicates that the immune system plays a critical role in the pathogenesis of cardiovascular diseases including hypertension. Mice lacking T lymphocytes are resistant to blood pressure elevation, suggesting a key contribution of T lymphocytes to hypertension. However, the individual T cell subsets, including CDS+, T(h)1, T(h)17, and T regulatory T cells have shown widely discrepant effects on blood pressure and target organ damage in this disorder. Moreover, the activation state of a T lymphocyte population exerts considerable influence over its role in hypertension. In turn, activated T cells regulate blood pressure through the elaboration of reactive oxygen species and vasoactive cytokines, altering the inflammatory milieu in the vascular wall and the kidney. Recent GWAS studies similarly point to a role for T lymphocytes in human hypertension.
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