期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 51, 期 2, 页码 677-685出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2017.4041
关键词
luteolin; angiogenesis; Gas6; Axl
类别
资金
- Science and Technology Program of China [2012ZX09103101-053]
- National Science Foundation of China [81573455]
- Guangdong Province [S2013050014183, 2013CXZDA006]
- Program for New Century Excellent Talents in University
- Pear River Scholar Funded Scheme
- Project for Constuction of Traditional Chinese Medicine Strong Province [20132114]
Growth arrest-specific protein 6 (Gas6) induces the activation of Axl receptor tyrosine kinase (Axl), which plays an important role in angiogenic processes, including proliferation, migration, invasion, tube formation and pericyte recruitment of endothelial cells. The inhibition of Gas6/Axl pathway has been demonstrated to be an effective anti-angiogenic therapy. Luteolin, which is a natural active flavonoid, has been reported to possess anti-angiogenic effects. However, the underlying mechanism of luteolin in anti-angiogenesis is not fully understood. Herein, we report that luteolin significantly inhibited the Gas6-induced proliferation, migration, invasion and tube formation of human microvascular endothelial cells (HMEC-1s) in vitro, and suppressed the Gas6-induced recruitment of human brain vascular pericytes (HBVPs) to the endothelial tubes. Luteolin also suppressed Gas6-induced microvessel sprouting in aortic ring assay and neovascularization in chick chorioallantoic membrane assay. The anti-angiogenic effect of luteolin may be associated with the inhibition of the Gas6/Axl pathway and its downstream phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathways. Taken together, the present study provides new evidence regarding an antiangiogenic mechanism of luteolin, and supports the notion that the dietary intake of luteolin contributes to the treatment of pathological angiogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据