期刊
CHEMICAL SCIENCE
卷 11, 期 24, 页码 6283-6288出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc01391a
关键词
-
资金
- NSFC [21672067]
- 973 Program [2015CB856600]
- Program of Eastern Scholar at Shanghai Institutions of Higher Learning and Program for Changjiang Scholars and Innovative Research Team [IRT-16R25]
A mild and practical Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization reaction of 2,3-dihydrofurans is developed, leading to various optically active fused furoindolines and tetrahydrofurobenzofurans. The key to this transformation is employing two newly modifiedN-Me-Xiang-Phos ligands ((S,R-S)-N-Me-X4/X5) as chiral ligands under mild conditions. Moreover, this synthetic methodology can be efficiently applied to a variety of complex polysubstituted heterocycles with high chemo-, regio-, and enantio-selectivitiesviaintroducing diverse substituents on furan rings, which were hard to access by other routes.
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