期刊
FOOD & FUNCTION
卷 11, 期 6, 页码 5192-5204出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo02554e
关键词
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资金
- National Natural Science Foundation of China [31671839, 31972052]
- National Natural Science Foundation of China Key Program [31530056]
- Fundamental Research Funds for the Central Universities [JUSRP51501]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- National First-Class Discipline Program of Food Science and Technology [JUFSTR20180102]
- Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
Polycystic ovarian syndrome (PCOS) is a common endocrine disease across the world. Because gut microbiota play a key role in the pathogenesis of PCOS, probiotics may alleviate PCOS symptoms through the regulation of intestinal flora. The effects of 8 lactic acid bacterial strains on PCOS were investigated. Letrozole was used to produce a PCOS rat model and a 4-week-strain-intervention was performed. Diane-35, as a clinical PCOS treatment medicine, was effective in attenuating rats' reproductive disorders.Lactobacillus plantarumHL2 was protective against ovary pathological changes and restored luteinizing hormone, follicle stimulating hormone and testosterone levels.Bifidobacterium longumHB3 also alleviated ovary abnormalities and decreased testosterone levels. Administration of lactic acid bacteria up-regulated short-chain fatty acid levels. Based on 16S rRNA sequencing, lactic acid bacteria improved letrozole induced gut microbiota dysbiosis with different degrees.Akkermansia,Roseburia,Prevotella,StaphylococcusandLactobacillusgenera were correlated with sex hormone levels. Some of the sex hormone-related gut microbiota were restored by treatment with the strains. These results demonstrated that lactic acid bacteria alleviated PCOS in a rat model by regulating sex hormone related gut microbiota. Modifying gut microbiota by probiotic interventions may thus be a promising therapeutic option for PCOS.
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