期刊
FOOD & FUNCTION
卷 11, 期 6, 页码 5473-5485出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo00546k
关键词
-
资金
- National Key R AMP
- D Program of China [2017YFD0400304]
- Project for the Public Service Platform of Strain Breeding and Fermentation Technology of Industrial Microorganisms [17PTGCCX00190]
- Innovative Research Team of Tianjin Municipal Education Commission [TD13-5015]
- Tianjin Natural Science Foundation [17JCZDJC33600]
Probiotics are thought to have immunomodulatory functions, improve inflammatory disorders and treat inflammatory bowel disease (IBD). Here, we screened a new probiotic strain with anti-inflammatory activity and investigated its effect on the immune cell response and histone acetylation.Lactobacillus casei(L. casei) LH23 inhibited the production of nitric oxide and inflammatory factors induced by lipopolysaccharides in RAW264.7 cells, which was associated with inhibiting the over-activation of the JNK/p38 signaling pathway. Furthermore,L. caseiLH23 can significantly ameliorate dextran sulfate sodium (DSS)-induced mouse colitisin vivoby reducing numbers of macrophages (CD11b(+)F4/80(+)) and their secreted inflammatory cytokines. Myeloperoxidase activity was also decreased in mice treated with LH23. The administration ofL. caseiLH23 induced the increase of CD3(+)CD4(+)CD25(+)regulatory T cells among mesenteric lymph nodes. Meanwhile, LH23 treatment could augment short chain fatty acid contents. Importantly, we reported here for the first time that DSS treatment significantly decreased the level of histone H3K9 acetylation, while supplementation ofL. caseiLH23 restored the level of histone H3K9 acetylation in colon tissues. These data suggest thatL. caseiLH23 may have been beneficial for preventing and treating IBD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据