期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 1369-1384出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S124276
关键词
C6 glioblastoma stem cells; apoptosis; blood-brain barrier; curcumin liposomes; brain glioma-bearing rats
资金
- National Science Foundation of China [81160540, 81460396]
- ShiHezi University Science Foundation of China [2012ZRKXJQ07]
- Foundation of Xinjiang Bingtuan [2015AD007]
Glioblastoma is a kind of malignant gliomas that is almost impossible to cure due to the poor drug transportation across the blood-brain barrier and the existence of glioma stem cells. We prepared a new kind of targeted liposomes in order to improve the drug delivery system onto the glioma cells and induce the apoptosis of glioma stem cells afterward. In this experiment, curcumin was chosen to kill gliomas, while quinacrine was used to induce apoptosis of the glioma stem cells. Also, p-aminophenyl-alpha-D-mannopyranoside could facilitate the transport of liposomes across the blood-brain barrier and finally target the brain glioma cells. The cell experiments in vitro indicated that the targeted liposomes could significantly improve the anti-tumor effects of the drugs, while enhancing the uptake effects, apoptosis effects, and endocytic effects of C6 glioma cells and C6 glioma stem cells. Given the animal experiments in vivo, we discovered that the targeted liposomes could obviously increase the survival period of brain glioma-bearing mice and inhibit the growth of gliomas. In summary, curcumin and quinacrine liposomes modified with p-aminophenyl-alpha-D-mannopyranoside is a potential preparation to treat brain glioma cells and brain glioma stem cells.
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