期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 4527-4539出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S129958
关键词
selenium; nano; microsphere; chitosan; antioxidant
资金
- Scientific and Technological Projects of Fujian Province, People's Republic of China [2016N0018]
- Scientific Research Foundation of Third Institute of Oceanography, State Oceanic Administration, People's Republic of China [2014010]
- Science & Technology Major Projects of Fujian province [2014NZ0001]
- Xiamen Oceanic Research and Development Institute
- Southern Ocean Research Center Project of Xiamen [13GYY001NF05]
- Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources
- Third Institute of Oceanography, State Oceanic Administration, Xiamen, Fujian, People's Republic of China
Selenium nanoparticles (SeNPs), as a special form of selenium (Se) supplement, have attracted worldwide attention due to their favorable properties and unique bioactivities. Herein, an eco-friendly and economic way to prepare stable SeNPs is introduced. SeNPs were synthesized in aqueous chitosan (CTS) and then embedded into CTS microspheres by spray-drying, forming selenium nanoparticles-loaded chitosan microspheres (SeNPs-M). The physicochemical properties including morphology, elemental state, size distribution and surface potential were investigated. Institute of Cancer Research mice were used as model animal to evaluate the bioactivities of SeNPs-M. Trigonal-phase SeNPs of similar to 35 nm were synthesized, and SeNPs-M physically embedding those SeNPs were successfully prepared. Amazingly, acute toxicity test indicated that SeNPs-M were much safer than selenite in terms of Se dose, with a LD50 of around 18-fold of that of selenite. In addition, SeNPs-M possessed powerful antioxidant activities, as evidenced by a dramatic increase of both Se retention and the levels of glutathione peroxidase, superoxide dismutase and catalase. The design of SeNPs-M can offer a new way for further development of SeNPs with a higher efficacy and better biosafety. Thus, SeNPs-M may be a potential candidate for further evaluation as an Se supplement with antioxidant properties and be used against Se deficiency in animals and human beings.
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