期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 615-632出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S116583
关键词
conductive polymers; nanoparticles; breast cancer; emulsion polymerization; nano-medicine; photothermal ablation; PEDOT; photothermal conversion efficiency; MDA-MB-231
资金
- National Science Foundation Partnership in Research and Education in Materials [DMR-1205670]
- Texas Emerging Technology Fund
- Robert A. Welch Foundation [AI-0045]
- Texas State Research Enhancement Program
- Texas State University Doctoral Research Support Fellowship
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1205670] Funding Source: National Science Foundation
Laser-mediated photothermal ablation of cancer cells aided by photothermal agents is a promising strategy for localized, externally controlled cancer treatment. We report the synthesis, characterization, and in vitro evaluation of conductive polymeric nanoparticles (CPNPs) of poly(diethyl-4,4'-{[2,5-bis(2,3-dihydrothieno[3,4-b][1,4] dioxin-5-yl)-1,4-phenylene] bis(oxy)} dibutanoate) (P1) and poly(3,4-ethylenedioxythiophene) (PEDOT) stabilized with 4-dodecylbenzenesulfonic acid and poly(4-styrenesulfonic acid-co-maleic acid) as photothermal ablation agents. The nanoparticles were prepared by oxidative-emulsion polymerization, yielding stable aqueous suspensions of spherical particles of <100 nm diameter as determined by dynamic light scattering and electron microscopy. Both types of nanoparticles show strong absorption of light in the near infrared region, with absorption peaks at 780 nm for P1 and 750 nm for PEDOT, as well as high photothermal conversion efficiencies (similar to 50%), that is higher than commercially available gold-based photothermal ablation agents. The nanoparticles show significant photostability as determined by their ability to achieve consistent temperatures and to maintain their morphology upon repeated cycles of laser irradiation. In vitro studies in MDA-MB-231 breast cancer cells demonstrate the cytocompatibility of the CPNPs and their ability to mediate complete cancer cell ablation upon irradiation with an 808-nm laser, thereby establishing the potential of these systems as agents for laser-induced photothermal therapy.
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