期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 2759-2767出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S131786
关键词
cell-derived nanovesicles; cell targeting; doxorubicin; antitumor therapy; extracellular vesicles; biomimetic; bionanotechnology; antitumor strategies
资金
- NUS, Department of Pharmacy (AcRF Tier 1 FRC grant) [R-148-000-213-112]
- NUS Graduate School for Integrative Sciences and Engineering
- Department of Pharmacy
- Electron Microscopy Unit (Yong Loo Lin School of Medicine, NUS)
Cell-derived nanovesicles (CDNs) are an emerging class of biological drug delivery systems (DDS) that retain the characteristics of the cells they were derived from, without the need for further surface functionalization. CDNs are also biocompatible, being derived from natural sources and also take advantage of the enhanced permeability and retention effect due to their nanodimensions. Furthermore, CDNs derived from monocytes were shown to have an in vivo targeting effect, accumulating at the tumor site in a previous study conducted in a mouse tumor model. Here, we report a systematic approach pertaining to various loading methods of the chemotherapeutic drug doxorubicin into our CDNs and examine the differential cellular uptake of drug-loaded CDNs in cancerous (HeLa) and healthy (HEK293) cell lines. Lastly, we proved that the addition of doxorubicin-loaded CDNs to the HeLa and HEK293 co-cultures showed a clear discrimination toward cancer cells at the cellular level. Our results further reinforce the intriguing potential of CDNs as an alternative targeted strategy for anticancer therapy.
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