期刊
INTERNATIONAL JOURNAL OF NANOMEDICINE
卷 12, 期 -, 页码 6317-6328出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S141794
关键词
MWCNTs; biomimetics; cytoskeleton; microtubules; apoptosis; migration; proliferation
资金
- Spanish MINECO Project [PI13/01074, PI16/00496, CTM2014-58481-R, IDIVAL INNVAL15/15]
- Xunta de Galicia (Centro Singular de Investigacion de Galicia- Accreditation) [EM2014/035]
- European Regional Development Fund ERDF
- Fundacion Tatiana Perez de Guzman El Bueno
Carbon nanotubes (CNTs) are likely to transform the therapeutic and diagnostic fields in biomedicine during the coming years. However, the fragmented vision of their side effects and toxicity in humans has proscribed their use as nanomedicines. Most studies agree that biocompatibility depends on the state of aggregation/dispersion of CNTs under physiological conditions, but conclusions are confusing so far. This study designs an experimental setup to investigate the cytotoxic effect of individualized multiwalled CNTs compared to that of identical nanotubes assembled on submicrometric structures. Our results demonstrate how CNT cytotoxicity is directly dependent on the nanotube dispersion at a given dosage. When CNTs are gathered onto silica templates, they do not interfere with cell proliferation or survival becoming highly compatible. These results support the hypothesis that CNT cytotoxicity is due to the biomimetics of these nanomaterials with the intracellular nanofilaments. These findings provide major clues for the development of innocuous CNT-containing nanodevices and nanomedicines.
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