期刊
NEW JOURNAL OF CHEMISTRY
卷 44, 期 24, 页码 10076-10086出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nj00045k
关键词
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资金
- Research Academic Cooperation Agreement CNRS/FAPESP-PRC project (France) [1688]
- SPRINT-Sao Paulo Researchers in International Collaboration (Brazil) [2016/50317-9]
- Algerian Ministry of Higher Education and Scientific Research
This paper describes the intercalation of ciprofloxacin (CIP), a bactericidal antibiotic, into the interlayer space of layered double hydroxides (LDHs). To counter the problem of bacterial resistance and also to improve the properties of the CIP drug, the drug carrier approach promises significant benefits. Through the tight control over the synthesis parameters, particularly the amounts of CIP with respect to aluminum ions, two different LDH-CIP-intercalated structures were obtained with significantly different interlayer distances, namely, 21 and 32 angstrom. The samples were fully characterized in terms of composition, structure, and morphology. Interestingly, the structure with the largest interlayer distance incorporated both CIP anions and Al(CIP)(3)complex, exhibiting the possibility to increase the CIP drug loading beyond the anionic-exchange capacity of the LDH carrier.In vitrorelease in a simulated intestinal fluid (phosphate-buffered solution at pH 7.5) confirmed that LDH was a potentially efficient carrier to deliver CIP in a sustained mannerviathe anion-exchange mechanism. Different release rates were observed depending on the intercalated structure, which were also influenced by the morphological characteristics.
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