期刊
BIOMATERIALS SCIENCE
卷 8, 期 12, 页码 3248-3269出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00263a
关键词
-
资金
- National Institutes of Health [R15GM104846, R15GM135875, R15GM112082, R15GM137298]
- Office of the Assistant Secretary of Defense for Health Affairs through the Defense Medical Research and Development Program [W81XWH1810610]
- U.S. Department of Defense (DOD) [W81XWH1810610] Funding Source: U.S. Department of Defense (DOD)
Biomimetic hydrogels have emerged as the most useful tissue engineering scaffold materials. Their versatile chemistry can recapitulate multiple physical and chemical features to integrate cells, scaffolds, and signaling molecules for tissue regeneration. Due to their highly hydrophilic nature hydrogels can recreate nutrient-rich aqueous environments for cells. Soluble regulatory molecules can be incorporated to guide cell proliferation and differentiation. Importantly, the controlled dynamic parameters and spatial distribution of chemical cues in hydrogel scaffolds are critical for cell-cell communication, cell-scaffold interaction, and morphogenesis. Herein, we review biomimetic hydrogels that provide cells with spatiotemporally controlled chemical cues as tissue engineering scaffolds. Specifically, hydrogels with temporally controlled growth factor-release abilities, spatially controlled conjugated bioactive molecules/motifs, and targeting delivery and reload properties for tissue engineering applications are discussed in detail. Examples of hydrogels that possess clinically favorable properties, such as injectability, self-healing ability, stimulus-responsiveness, and pro-remodeling features, are also covered.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据