期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms18061239
关键词
lncRNA; GWAS; genomics; transcription factor; SNP; cancer
资金
- Academy of Finland [284618, 279760]
- University of Oulu Strategic Funds
- Jane AMP
- Aatos Erkko Foundation
- Academy of Finland (AKA) [284618, 279760, 284618, 279760] Funding Source: Academy of Finland (AKA)
With the development of advanced genomic methods, a large amount of long non-coding RNAs (lncRNAs) have been found to be important for cancer initiation and progression. Given that most of the genome-wide association study (GWAS)-identified cancer risk SNPs are located in the noncoding region, the expression and function of lncRNAs are more likely to be affected by the SNPs. The SNPs may affect the expression of lncRNAs directly through disrupting the binding of transcription factors or indirectly by affecting the expression of regulatory factors. Moreover, SNPs may disrupt the interaction between lncRNAs and other RNAs or proteins. Unveiling the relationship of lncRNA, protein-coding genes, transcription factors and miRNAs from the angle of genomics will improve the accuracy of disease prediction and help find new therapeutic targets.
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