期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms18030456
关键词
microRNA; type 2 diabetesmellitus; miRNA-mRNA interaction network; systematic study
资金
- Talents Recruitment Grant of Yangfan Plan of Guangdong Province, China [201433005]
- Science and Technology Program of Guangdong [2013B051000080]
- International Science & Technology Cooperation Program of Dongguan [2013508152005, 20135081520017]
- Science & Technology Program of Dongguan [2014108101055]
- Innovation Project from the Education Department of Guangdong Province [2015KTSCX048y]
- National Science Foundation of China [81273166]
- NIH [U01HL126496-02]
MicroRNAs (miRNAs) are small noncoding RNAs that modulate the cellular transcriptome at the post-transcriptional level. miRNA plays important roles in different disease manifestation, including type 2 diabetes mellitus (T2DM). Many studies have characterized the changes of miRNAs in T2DM, a complex systematic disease; however, few studies have integrated these findings and explored the functional effects of the dysregulated miRNAs identified. To investigate the involvement of miRNAs in T2DM, we obtained and analyzed all relevant studies published prior to 18 October 2016 from various literature databases. From 59 independent studies that met the inclusion criteria, we identified 158 dysregulated miRNAs in seven different major sample types. To understand the functional impact of these deregulated miRNAs, we performed targets prediction and pathway enrichment analysis. Results from our analysis suggested that the altered miRNAs are involved in the core processes associated with T2DM, such as carbohydrate and lipid metabolisms, insulin signaling pathway and the adipocytokine signaling pathway. This systematic survey of dysregulated miRNAs provides molecular insights on the effect of deregulated miRNAs in different tissues during the development of diabetes. Some of these miRNAs and their mRNA targets may have diagnostic and/or therapeutic utilities in T2DM.
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