期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms18020336
关键词
nanoparticles; macrophage; polarization; reprogramming
资金
- National Natural Science Foundation of China [90913006, 20902054, 21307077]
- Ministry of Education of China [20130131120007]
- China Postdoctoral Science Foundation funded project [2013M541920, 2014T70642]
- Natural Science Foundation of Shandong Province [ZR2013BQ026, ZR2014HM113]
- Fundamental Research Funds of Shandong University [2016JC006]
Macrophages are vital regulators of the host defense in organisms. In response to different local microenvironments, resting macrophages (M0) can be polarized into different phenotypes, pro-inflammatory (M1) or anti-inflammatory (M2), and perform different roles in different physiological or pathological conditions. Polarized macrophages can also be further reprogrammed by reversing their phenotype according to the changed milieu. Macrophage polarization and reprogramming play essential roles in maintaining the steady state of the immune system and are involved in the processes of many diseases. As foreign substances, nanoparticles (NPs) mainly target macrophages after entering the body. NPs can perturb the polarization and reprogramming of macrophages, affect their immunological function and, therefore, affect the pathological process of disease. Optimally-designed NPs for the modulation of macrophage polarization and reprogramming might provide new solutions for treating diseases. Systematically investigating how NPs affect macrophage polarization is crucial for understanding the regulatory effects of NPs on immune cells in vivo. In this review, macrophage polarization by NPs is summarized and discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据