期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/ijms18050905
关键词
matrix metalloproteinase; rheumatoid arthritis; epigenetics; gene transcription
资金
- JSPS KAKENHI Grant [16K09903, 16K09902]
- Saitama Medical University Hospital [28-E-1-05]
- Japan Agency for Medical Research and development, AMED [15ek0109019h0002]
- Grants-in-Aid for Scientific Research [16K09903, 16K09902] Funding Source: KAKEN
Matrix metalloproteinases (MMPs) are implicated in the degradation of extracellular matrix (ECM). Rheumatoid arthritis (RA) synovial fibroblasts (SFs) produce matrix-degrading enzymes, including MMPs, which facilitate cartilage destruction in the affected joints in RA. Epigenetic mechanisms contribute to change in the chromatin state, resulting in an alteration of gene transcription. Recently, MMP gene activation has been shown to be caused in RASFs by the dysregulation of epigenetic changes, such as histone modifications, DNA methylation, and microRNA (miRNA) signaling. In this paper, we review the role of MMPs in the pathogenesis of RA as well as the disordered epigenetic mechanisms regulating MMP gene activation in RASFs.
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