期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms18020244
关键词
mesenchymal stem cells; stem cell therapy; immunomodulation; inflammatory skin diseases; atopic dermatitis; psoriasis
资金
- Cooperative Research Program for Agriculture Science & Technology Development, Rural Development Administration, Republic of Korea [PJ01100201]
- Research Institute for Veterinary Science, Seoul National University, Korea
Inflammatory skin disorders that cause serious deterioration of the quality of life have become one of the major public concerns. Despite their significance, there is no fundamental cure to date. Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties which make them a promising tool for the treatment of various inflammatory diseases. Our recent preclinical and clinical studies have shown that MSCs can be successfully used for the treatment of atopic dermatitis (AD), one of the major inflammatory skin diseases. This observation along with similar reports from other groups revealed the efficacy and underlying mechanisms of MSCs in inflammatory dermatosis. In addition, it has been proposed that cell priming or gene transduction can be novel strategies for the development of next-generation high-efficacy MSCs for treating inflammatory skin diseases. We discuss here existing evidence that demonstrates the regulatory properties of MSCs on immune responses under inflammatory conditions.
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