期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/ijms18040673
关键词
melatonin; effect; liver injuries; steatosis; fatty liver; hepatitis; fibrosis; cirrhosis; hepatocarcinoma
资金
- National Natural Science Foundation of China [81372976]
- Key Project of Guangdong Provincial Science and Technology Program [2014B020205002]
- Hundred-Talents Scheme of Sun Yat-sen University
Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.
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