期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ijms18020448
关键词
proteome; proteomics; drug development; early phase development; clinical development; biomarker; Omics; clinical research; phase 0; phase 1; phase 2; proof-of-concept; proof-of-mechanism; proof-of-principle; first-in-human (FIH) studies; pharmacogenomics; pharmacometabolomics; pharmacokinetics (PK); pharmacodynamics (PD); drug toxicity
Pharmacoproteomics is the study of disease-modifying and toxicity parameters associated with therapeutic drug administration, using analysis of quantitative and temporal changes to specific, predetermined, and select proteins, or to the proteome as a whole. Pharmacoproteomics is a rapidly evolving field, with progress in analytic technologies enabling processing of complex interactions of large number of unique proteins and effective use in clinical trials. Nevertheless, our analysis of clinicaltrials.gov and PubMed shows that the application of proteomics in early-phase clinical development is minimal and limited to few therapeutic areas, with oncology predominating. We review the history, technologies, current usage, challenges, and potential for future use, and conclude with recommendations for integration of pharmacoproteomic in early-phase drug development.
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