期刊
CURRENT OPINION IN OPHTHALMOLOGY
卷 26, 期 3, 页码 226-232出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/ICU.0000000000000140
关键词
optogenetic tools; retina; vision restoration
资金
- Labex Lifesenses [ANR-10-LABX-65]
- ERC [309776]
- European Research Council (ERC) [309776] Funding Source: European Research Council (ERC)
Purpose of review In this review, we will discuss the recent developments in optogenetics and their potential applications in ophthalmology to restore vision in retinal degenerative diseases. Recent findings In recent years, we have seen major advances in the field of optogenetics, providing us with novel opsins for potential applications in the retina. Microbial opsins with improved light sensitivity and red-shifted action spectra allow optogenetic stimulation at light levels well below the safety threshold in the human eye. In parallel, remarkable success in the development of highly efficient viral vectors for ocular gene therapy led to new strategies of using these novel optogenetic tools for vision restoration. Summary These recent findings show that novel optogenetic tools and viral vectors for ocular gene delivery are now available providing many opportunities to develop potential optogenetic strategies for vision restoration.
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