4.7 Article

Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A

期刊

CHEMICAL COMMUNICATIONS
卷 56, 期 55, 页码 7565-7568

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03055d

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资金

  1. University of Georgia [DE-SC0015662]
  2. NIH [T32 GM067550, GM107550]
  3. Woolf Fisher Trust
  4. Leverhulme Trust
  5. Isaac Newton Trust

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Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter.

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