期刊
CELL ADHESION & MIGRATION
卷 14, 期 1, 页码 118-128出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2020.1767489
关键词
Heparin; low-molecular-weight heparin; heparin derivatives; cancer; metastasis
类别
资金
- National Natural Science Foundation of China [81901883, 81801827, 81872365]
- Basic Research Program of Jiangsu Province [BK20181086, BK20191080]
- National Key Research and Development Program of China [2016YFC0905900]
Heparin, including unfractionated heparin (UFH), low-molecular-weight heparin (LMWH) and heparin derivatives, are commonly used in venous thromboembolism treatment and reportedly have beneficial effects on cancer survival. Heparin can affect the proliferation, adhesion, angiogenesis, migration and invasion of cancer cells via multiple mechanisms. The main mechanisms involve inhibition of heparanase, P-/L-selectin, angiogenesis, and interference with the CXCL12-CXCR4 axis. Here we summarize the current experimental evidence regarding the anti-cancer role of heparin and its derivatives, and conclude that there is evidence to support heparin's role in inhibiting cancer progression, making it a promising anti-cancer agent.
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