期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms18091921
关键词
insulin; IGF system; glycans; cancer; glycosylation
资金
- Portugal: Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP) integrates the i3S research unit
- Portuguese Foundation for Science and Technology (FCT)
- Norte Portugal Regional Programme (NORTE) under the PORTUGAL Partnership Agreement through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000029]
- FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE -Operacional Programme for Competitiveness and Internationalisation (POCI), Portugal
- Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia/ Ministerio da Ciencia, Tecnologia e Inovacao [POCI-01/0145-FEDER-016601]
- Brazil: Ministerio da Saude
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [336/13]
The insulin/insulin-like growth factor (IGF) system in mammals comprises a dynamic network of proteins that modulate several biological processes such as development, cell growth, metabolism, and aging. Dysregulation of the insulin/IGF system has major implications for several pathological conditions such as diabetes and cancer. Metabolic changes also culminate in aberrant glycosylation, which has been highlighted as a hallmark of cancer. Changes in glycosylation regulate every pathophysiological step of cancer progression including tumour cell-cell dissociation, cell migration, cell signaling and metastasis. This review discusses how the insulin/IGF system integrates with glycosylation alterations and impacts on cell behaviour, metabolism and drug resistance in cancer.
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