期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 35, 期 1, 页码 1433-1441出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756366.2020.1786819
关键词
alpha-Mangostin; gamma-mangostin; Garcinia mangostana; LC-QTOF-MS; xanthone; cholinesterase inhibition
资金
- Universiti Sains Malaysia
- Fundamental Research Grant Scheme (FRGS) from Ministry of Higher Education Malaysia [203/PFARMASI/6711539]
- Ministry of Higher Education Malaysia
Mangosteen is one of the best tasting tropical fruit widely cultivated in Southeast Asia. This study aimed to quantify xanthone content in different parts ofGarcinia mangostanaby LC-QTOF-MS and determine its influence on their cholinesterase inhibitory activities. The total xanthone content inG. mangostanawas in the following order: pericarp > calyx > bark > stalk > stem > leaves > aril. The total xanthone content of pericarp was 100 times higher than the aril. Methanol extracts of the pericarp and calyx demonstrated the most potent inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC(50)values of 0.90 and 0.37 mu g/mL, respectively. Statistical analysis showed a strong correlation between xanthone content and cholinesterase inhibition. Nonmetric multidimensional scaling analysis revealed alpha-mangostin and gamma-mangostin of pericarp as the key metabolites contributing to cholinesterase inhibition. Due to the increasing demand of mangosteen products, repurposing of fruit waste (pericarp) has great potential for enhancement of the cognitive health of human beings.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据