期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms18061282
关键词
Metformin; postprandial hypertriglyceridemia; gastric emptying
资金
- Shiga University of Medical Science
- Astellas
- Boehringer-Ingelheim
- Daiichi-Sankyo
- Kowa Pharmaceuticals
- Kyowa-hakko-Kirin
- Mitsubishi Tanabe
- MSD
- Nipro
- Ono Pharmaceutical
- Pfizer
- Sanofi
- Sanwa Kagaku Kenkyusho
- Shionogi
- Taisho-Toyama
- Takeda
- Teijin Pharma
Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the triglyceride-lowering effect of metformin. Here, we examined the effects of metformin on lipid metabolism after olive oil-loading in 129S mice fed a high fat diet for three weeks. Metformin administration (250 mg/kg) for one week decreased postprandial plasma triglycerides. Pre-administration (250 mg/kg) of metformin resulted in a stronger triglyceride-lowering effect (approximately 45% lower area under the curve) than post-administration. A single administration (250 mg/kg) of metformin lowered plasma postprandial triglycerides comparably to administration for one week, suggesting an acute effect of metformin on postprandial hypertriglyceridemia. To explore whole body lipid metabolism after fat-loading, stomach size, fat absorption in the intestine, and fat oxidation (C-13/C-12 ratio in expired CO2 after administration of glyceryl-1-C-13 tripalmitate) were measured with and without metformin (250 mg/kg) pre-treatment. In metformin-treated mice, larger stomach size, lower fat oxidation, and no change in lipid absorption were observed. In conclusion, metformin administration before fat loading reduced postprandial hypertriglyceridemia, most likely by delaying gastric emptying.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据