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Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
SY Peng et al.
JOURNAL OF NEUROCHEMISTRY (2005)
The role of insulin receptor signaling in the brain
L Plum et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2005)
ER stress and the unfolded protein response
M Schröder et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
S Hoyer
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
JW Lustbader et al.
SCIENCE (2004)
Effect of antioxidant flavanone, naringenin, from Citrus junos on neuroprotection
HJ Heo et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: Implications for Alzheimer's disease intervention
LX Zhao et al.
JOURNAL OF NEUROSCIENCE (2004)
Intranasal insulin improves memory in humans
C Benedict et al.
PSYCHONEUROENDOCRINOLOGY (2004)
Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice
F Li et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Role of extracellular signal regulated kinases 1 and 2 in neuronal survival
M Hetman et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2004)
Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells
SS Kang et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Enhanced brain levels of 8,12-iso-iPF2α-VI differentiate AD from frontotemporal dementia
Y Yao et al.
NEUROLOGY (2003)
Insulin increases CSF Aβ42 levels in normal older adults
GS Watson et al.
NEUROLOGY (2003)
The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress - elucidation by GADD34-deficient mice
E Kojima et al.
FASEB JOURNAL (2003)
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
W Farris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease
B Michalski et al.
MOLECULAR BRAIN RESEARCH (2003)
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1α to the endoplasmic reticulum and promotes dephosphorylation of the α subunit of eukaryotic translation initiation factor 2
MH Brush et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
17β-estradiol and the phytoestrogen genistein attenuate neuronal apoptosis induced by the endoplasmic reticulum calcium-ATPase inhibitor thapsigargin
NJ Linford et al.
STEROIDS (2002)
Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease
DG Nicholls
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2002)
Alzheimer's disease is a synaptic failure
DJ Selkoe
SCIENCE (2002)
Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
T Okada et al.
BIOCHEMICAL JOURNAL (2002)
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
H Nishitoh et al.
GENES & DEVELOPMENT (2002)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities
CS Casley et al.
JOURNAL OF NEUROCHEMISTRY (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
Subcellular distribution of superoxide dismutases (SOD) in rat liver - Cu,Zn-SOD in mitochondria
A Okado-Matsumoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Glutathione-S-transferase family of enzymes
RC Strange et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2001)
Trk receptors: mediators of neurotrophin action
A Patapoutian et al.
CURRENT OPINION IN NEUROBIOLOGY (2001)
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2α
I Novoa et al.
JOURNAL OF CELL BIOLOGY (2001)
Caspase cleavage enhances the apoptosis-inducing effects of BAD
F Condorelli et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
T Yoneda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
KD McCullough et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
MG Murer et al.
PROGRESS IN NEUROBIOLOGY (2001)
Role of free radicals in the neurodegenerative diseases - Therapeutic implications for antioxidant treatment
B Halliwell
DRUGS & AGING (2001)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
J Ye et al.
MOLECULAR CELL (2000)
Neurotrophin signal transduction in the nervous system
DR Kaplan et al.
CURRENT OPINION IN NEUROBIOLOGY (2000)
Mitochondria and cell death
AP Halestrap et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
T Nakagawa et al.
NATURE (2000)
Heme oxygenase-1: role in brain aging and neurodegeneration
HM Schipper
EXPERIMENTAL GERONTOLOGY (2000)
Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia
WR Schabitz et al.
STROKE (2000)
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