期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/ijms18061161
关键词
microRNAs; wheat starch; glucose and lipid metabolism; Megalobrama amblycephala
资金
- National Natural Science Foundation of China [31602177, 31472289]
- Central Public-Interest Scientific Institution Basal Research Fund
- Freshwater Fisheries Research Center, CAFS [2017JBFM05]
- Earmarked Fund for China Agriculture Research System [CARS-46]
Blunt snout bream (Megalobrama amblycephala) is a widely favored herbivorous fish species and is a frequentlyused fish model for studying the metabolism physiology. This study aimed to provide a comprehensive illustration of the mechanisms of a high-starch diet (HSD) induced lipid metabolic disorder by identifying microRNAs (miRNAs) controlled pathways in glucose and lipid metabolism in fish using high-throughput sequencing technologies. Small RNA libraries derived from intestines, livers, and brains of HSD and normal-starch diet (NSD) treated M. amblycephala were sequenced and 79, 124 and 77 differentially expressed miRNAs (DEMs) in intestines, livers, and brains of HSD treated fish were identified, respectively. Bioinformatics analyses showed that these DEMs targeted hundreds of predicted genes were enriched into metabolic pathways and biosynthetic processes, including peroxisome proliferator-activated receptor (PPAR), glycolysis/gluconeogenesis, and insulin signaling pathway. These analyses confirmed that miRNAs play crucial roles in glucose and lipid metabolism related to high wheat starch treatment. These results provide information on further investigation of a DEM-related mechanism dysregulated by a high carbohydrate diet.
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